Multicentric study on the reproducibility and robustness of PET-based radiomics features with a realistic activity painting phantom.

ABSTRACT: Previously, we developed an "activity painting" tool for PET image simulation; however, it could simulate heterogeneous patterns only in the air. We aimed to improve this phantom technique to simulate arbitrary lesions in a radioactive background to perform relevant multi-center radiomic analysis. We conducted measurements moving a 22Na point source in a 20-liter background volume filled with 5 kBq/mL activity with an adequately controlled robotic system to prevent the surge of the water. Three different lesion patterns were "activity-painted" in five PET/CT cameras, resulting in 8 different reconstructions. We calculated 46 radiomic indeces (RI) for each lesion and imaging setting, applying absolute and relative discretization. Reproducibility and reliability were determined by the inter-

SUBMITTER: Kallos-Balogh P 

PROVIDER: S-EPMC11500893 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature