Epigenetic aging differentially impacts breast cancer risk by self-reported race.

ABSTRACT:

Background

Breast cancer (BrCa) is the most common cancer for women globally. BrCa incidence varies by age and differs between racial groups, with Black women having an earlier age of onset and higher mortality compared to White women. The underlying biological mechanisms of this disparity remain uncertain. Here, we address this knowledge gap by examining the association between overall epigenetic age acceleration and BrCa initiation as well as the mediating role of race.

Results

We measured whole-genome methylation (866,238 CpGs) using the Illumina EPIC array in blood DNA extracted from 209 women recruited from University Hospitals Cleveland Medical Center. Overall and intrinsic epigenetic age acceleration was calculated-accounting for the estimated white blood cell distrib

SUBMITTER: Wu Y 

PROVIDER: S-EPMC11500918 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature