Diagnostic serology test comparison for Q fever and Rift Valley fever in humans and livestock from pastoral communities.

ABSTRACT: Q fever (QF) and Rift Valley fever (RVF) are endemic zoonotic diseases in African countries, causing significant health and economic burdens. Accurate prevalence estimates, crucial for disease control, rely on robust diagnostic tests. While enzyme-linked immunosorbent assays (ELISA) are not the gold standard, they offer rapid, cost-effective, and practical alternatives. However, varying results from different tests and laboratories can complicate comparing epidemiological studies. This study aimed to assess the agreement of test results for QF and RVF in humans and livestock across different laboratory conditions and, for humans, different types of diagnostic tests. We measured inter-laboratory agreement using concordance, Cohen's kappa, and prevalence and bias-adjusted kappa (PABAK) on 91

SUBMITTER: Hungerbuhler V 

PROVIDER: S-EPMC11501034 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature