Increasing adult-born neurons protects mice from epilepsy.

ABSTRACT: Neurogenesis occurs in the adult brain in the hippocampal dentate gyrus, an area that contains neurons which are vulnerable to insults and injury, such as severe seizures. Previous studies showed that increasing adult neurogenesis reduced neuronal damage after these seizures. Because the damage typically is followed by chronic life-long seizures (epilepsy), we asked if increasing adult-born neurons would prevent epilepsy. Adult-born neurons were selectively increased by deleting the pro-apoptotic gene Bax from Nestin-expressing progenitors. Tamoxifen was administered at 6 weeks of age to conditionally delete Bax in Nestin-CreER^T2Bax^fl/fl mice. Six weeks after tamoxifen administration, severe seizures (status epilepticus; SE) were induced by inject

SUBMITTER: Jain S 

PROVIDER: S-EPMC11501206 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature