Ultrasensitive label-free miRNA-21 detection based on MXene-enhanced plasmonic lateral displacement measurement.

ABSTRACT: miRNAs are small non-coding RNA molecules which serve as promising biomarkers due to their important roles in the development and progression of various cancer types. The detection of miRNAs is of vital importance to the early-stage diagnostics and prognostics of multiple diseases. However, traditional detection strategies have faced some challenges owing to the intrinsic characteristics of miRNAs including small size, short sequence length, low concentration level and high sequence homology in complex real samples. To overcome these challenges, we proposed a MXene-enhanced plasmonic biosensor for real-time and label-free detection of miRNA. By utilizing MXene nanomaterial which possesses unique characteristics including large surface area and strong carrier confinement abilities, we tuned

SUBMITTER: Wang Y 

PROVIDER: S-EPMC11501375 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature