A new model and precious tool to study molecular mechanisms of macrophage aging.

ABSTRACT: The accumulation of senescent cells, characterized by a senescence-associated secretory phenotype (SASP), contributes to chronic inflammation and age-related diseases (ARD). During aging, macrophages can adopt a senescent-like phenotype and an altered function, which promotes senescent cell accumulation. In the context of aging and ARD, controlling the resolution of the inflammatory response and preventing chronic inflammation, especially by targeting macrophages, must be a priority. Aging being a dynamic process, we developed a model of in vitro murine peritoneal macrophage aging. Our results show that macrophages cultured for 7 or 14 days exhibit a senescence-like phenotype: proliferation decrease, the levels of cyclin-dependent kinase inhibitors p16^INK4A and p21^CI

SUBMITTER: Smith R 

PROVIDER: S-EPMC11501386 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature