Identification of metabolomic changes and potential therapeutic targets during ovarian aging.

ABSTRACT:

Purpose

To reveal the metabolic differences of follicle fluid (FF) and granulosa cell (GC) between younger women and advanced age women in ART cycles, and then find potential therapeutic targets of ovarian aging.

Methods

Forty-five patients were included in the study and they were divided into three groups according to their age (Group A: 20-30 years old; Group B: 30-35 years old; Group C: 35-45 years old). All patients underwent controlled ovarian stimulation using the follicular phase long-acting protocol, FF and GC were obtained 36-38 hours after HCG administration. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) was used for metabolomics analysis and metabolic pathway analysis (MetPA) was utilized to find related pathways.

Results

Between group A and gro

SUBMITTER: Sun B 

PROVIDER: S-EPMC11501388 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature