Highly efficient upconversion photodynamic performance of rare-earth-coupled dual-photosensitizers: ultrafast experiments and excited-state calculations.

ABSTRACT: Upconversion photodynamic therapy (UC-PDT), which integrates upconversion nanoparticles (UCNPs) with photosensitizers (PSs), presents a promising advancement in the field of phototherapy. However, despite the extensive studies focused on the design and synthesis of UCNPs, there is a paucity of systematic research on the mechanisms underlying the synergistic upconversion photodynamic effects. Here we have synthesized upconversion core@dotted-shell nanoparticles (CDSNPs) and covalently tethered them with two distinct PSs, thereby constructing a dual-PS UC-PDT system with high synergistic photodynamic performance. To unravel the mechanism underlying the synergism, we employed a combination of quantum mechanical calculations and ultrafast time-resolved spectroscopy techniques. The results indi

SUBMITTER: Yang Y 

PROVIDER: S-EPMC11501619 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature