<i>Atp13a5</i> Marker Reveals Pericyte Specification in the Mouse Central Nervous System.

ABSTRACT: Perivascular mural cells including vascular smooth cells (VSMCs) and pericytes are integral components of the vascular system. In the central nervous system (CNS), pericytes are also indispensable for the blood-brain barrier (BBB), blood-spinal cord barrier, and blood-retinal barrier and play key roles in maintaining cerebrovascular and neuronal functions. However, the functional specifications of pericytes between CNS and peripheral organs have not been resolved at the genetic and molecular levels. Hence, the generation of reliable CNS pericyte-specific models and genetic tools remains very challenging. Here, we report a new CNS pericyte marker in mice. This putative cation-transporting ATPase 13A5 (Atp13a5) marker was identified through single-cell transcriptomics, based on its sp

SUBMITTER: Guo X 

PROVIDER: S-EPMC11502228 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature