Differential evaluation of neuromuscular injuries to understand re-innervation at the neuromuscular junction.

ABSTRACT: Peripheral nerve-crush injury is a well-established model of neuromuscular junction (NMJ) denervation and subsequent re-innervation. Functionally, the skeletal muscle follows a similar pattern as neural recovery, with immediate loss of force production that steadily improves in parallel with rates of re-innervation. On the other hand, traumatic injury to the muscle itself, specifically volumetric muscle loss (VML), results in an irrecoverable loss of muscle function. Recent work has indicated significant impairments to the NMJ following this injury that appear chronic in nature, alongside the lack of functional recovery. Thus, the goal of this study was to compare the effects of nerve and muscle injury on NMJ remodeling. Even numbers of adult male and female mice were used with three exper

SUBMITTER: Hoffman DB 

PROVIDER: S-EPMC11502237 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature