Mobility trajectories in multiple sclerosis: A comparative study of timed 25-foot walk and a patient-reported outcome measure.

ABSTRACT:

Background

Loss of mobility is common in persons with multiple sclerosis (PwMS), but little is known about this impairment from the patient's perspective.

Objective

The aim is to model longitudinal variation in a mobility patient-reported outcome (PRO) and compare trajectories to those observed for Timed 25-Foot Walk (T25FW) in a retrospective cohort.

Methods

Latent-class growth analysis was applied to 47,508 measures of Performance Scales© Mobility PRO (PS-Mobility) over ~4 years for 8524 PwMS. For 7347 PwMS, there were 41,988 T25FW measures during this period. Repeated measures correlation and concordance of trajectory assignment were evaluated.

Results

At the group level, PS-Mobility and T25FW linearly worsened and repeated-measures correlation was moderate.

SUBMITTER: Briggs FB 

PROVIDER: S-EPMC11502245 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature