Trauma patients with type O blood exhibit unique multiomics signature with decreased lectin pathway of complement levels.

ABSTRACT:

Background

Patients with type O blood may have an increased risk of hemorrhagic complications because of lower baseline levels of von Willebrand factor and factor VIII, but the transition to a mortality difference in trauma is less clear. We hypothesized that type O trauma patients will have differential proteomic and metabolomic signatures in response to trauma beyond von Willebrand factor and factor VIII alone.

Methods

Patients meeting the highest level of trauma activation criteria were prospectively enrolled. Blood samples were collected upon arrival to the emergency department. Proteomic and metabolomic (multiomics) analyses of these samples were performed using liquid chromatography-mass spectrometry. Demographic, clinical, and multiomics data were compared between pat

SUBMITTER: Stocker BW 

PROVIDER: S-EPMC11502284 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature