Association of mutation profiles with metastasis in patients with non-small cell lung cancer.

ABSTRACT:

Objective

This study focused on the analysis of the correlation between common gene mutation types and metastatic sites in NSCLC patients.

Methods

We retrospectively studied 1586 NSCLC patients and used fluorescence Polymerase chain reaction (PCR) to detect EGFR, ALK, ROS1, RET, MET, BRAF, HER2, KRAS, NRAS, and PIK3CA gene mutations, and also investigated sex, smoking status, age at diagnosis, histological type and TNM stage. In addition, we analyzed the site of metastasis in patients with stage IV NSCLC.

Results

The EGFR-mutation group more frequently metastasized to lung (18.9%, P = 0.004), brain (18.9%, P = 0.001) and bone (27.1%, P = 0.004) than wild-type patients. ALK-mutation group (71.0%, P < 0.001), BRAF-mutation group (82.4%, P = 0.005) and NRAS-mutation grou

SUBMITTER: Li Y 

PROVIDER: S-EPMC11502319 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature