Association of frailty and serum neurofilament light chain levels: the mediating role of estimated glomerular filtration rate.

ABSTRACT:

Background

Both frailty and elevated serum neurofilament light chain (sNfL) levels are linked to cognitive impairment. However, evidence of their relationship is lacking, and whether it was mediated by renal function was unknown. This study aimed to investigate the association between frailty and sNfL levels in a representative U.S. population, and to explore the potential mediating role of estimated glomerular filtration rate (eGFR) in this relationship.

Methods

Data from 1,782 participants aged 20-75 years in the 2013-2014 National Health and Nutrition Examination Survey (NHANES) were analyzed. Frailty was assessed using a 49-item frailty index, and participants were categorized as non-frail, pre-frail, or frail. sNfL levels were measured using acoustic emission technology

SUBMITTER: Yang W 

PROVIDER: S-EPMC11502322 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature