Toll-like receptor 7 protects against intestinal inflammation and restricts the development of colonic tissue-resident memory CD8⁺ T cells.

ABSTRACT:

Introduction

The maintenance of intestinal homeostasis depends on a complex interaction between the immune system, intestinal epithelial barrier, and microbiota. Alteration in one of these components could lead to the development of inflammatory bowel diseases (IBD). Variants within the autophagy gene ATG16L1 have been implicated in susceptibility and severity of Crohn's disease (CD). Individuals carrying the risk ATG16L1 T300A variant have higher caspase 3-dependent degradation of ATG16L1 resulting in impaired autophagy and increased cellular stress. ATG16L1-deficiency induces enhanced IL-1β secretion in dendritic cells in response to bacterial infection. Infection of ATG16L1-deficient mice with a persistent strain of murine norovirus renders these mice highly suscep

SUBMITTER: Hamade H 

PROVIDER: S-EPMC11502343 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature