Mitochondrial haplogroup R offers protection against obesity in Kuwaiti and Qatari populations.

ABSTRACT:

Background

The Kuwaiti and Qatari populations have a high prevalence of obesity, a major risk factor for various metabolic disorders. Previous studies have independently explored mitochondrial DNA (mtDNA) variations and their association with obesity in these populations. This study aims to investigate the role of mtDNA haplogroups and variants in obesity risk among these Gulf populations.

Methods

Whole exome sequencing data from 1,112 participants (348 Kuwaitis and 764 Qataris) were analyzed for mtDNA variants. Participants were classified as obese or non-obese based on body mass index (BMI). Association analyses were performed to examine the relationship between mtDNA haplogroups and obesity, adjusting for covariates such as age and sex.

Results

Haplogroup R was fou

SUBMITTER: Dashti M 

PROVIDER: S-EPMC11502345 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature