Prognostic role of lymph node regression in patients with esophageal cancer undergoing neoadjuvant therapy.

ABSTRACT:

Purpose

To clarify the prognostic value of lymph node regression (LNR) status including the lymph node regression grade (LNRG) and N downstaging in patients with esophageal cancer receiving neoadjuvant therapy based on available evidence.

Methods

Several databases were searched up to 25 March 2024. The main outcomes included overall survival (OS), disease-free survival (DFS) and cancer-specific survival (CSS). Hazard ratios (HRs) and 95% confidence intervals (CIs) were combined. Subgroup analyses based on the neoadjuvant therapy and pathological type were also conducted.

Results

In total, 14 retrospective studies with 3,212 participants were included. Nine and five studies explored the relationship between LNRG and N downstaging and survival, respectively. Pooled resu

SUBMITTER: Chen P 

PROVIDER: S-EPMC11502349 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature