Association between vitamin B6 levels and rheumatoid arthritis: a two-sample Mendelian randomization study.

ABSTRACT:

Background

Micronutrients play a crucial role in rheumatoid arthritis (RA). Changes in micronutrient levels in RA patients can lead to the worsening of their condition. Though significant correlations between RA and micronutrients have been found in earlier observational studies, their underlying causal relationship is still unknown. This study aimed to elucidate the causal genetic relationships between 15 micronutrients (copper, zinc, magnesium, vitamins A, C, E, D, B6, B12, folate, carotene, iron, selenium, calcium, potassium) and RA.

Method

The exposure factors and outcome data used in the two-sample Mendelian randomization (MR) were derived from publicly available summary statistics data of European populations. The GWAS data for exposure factors were obtained from the O

SUBMITTER: Liu Y 

PROVIDER: S-EPMC11502391 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature