Genetically stratified Parkinson's disease with freezing of gait is related to specific pattern of cognitive impairment and non-motor dominant endophenotype.

ABSTRACT:

Background

Freezing of gait (FOG) is an important milestone in the individual disease trajectory of people with Parkinson's disease (PD). Based on the cognitive model of FOG etiology, the mechanism behind FOG implies higher executive dysfunction in PD^FOG+. To test this model, we investigated the FOG-related phenotype and cognitive subdomains in idiopathic PD (iPD) patients without genetic variants linked to PD from the Luxembourg Parkinson's study.

Methods

A cross-sectional analysis comparing iPD^FOG+ (n = 118) and iPD^FOG- (n = 378) individuals was performed, followed by the application of logistic regression models. Consequently, regression models were fitted for a subset of iPD^FOG+ (n = 35) vs. iPD

SUBMITTER: Pavelka L 

PROVIDER: S-EPMC11502444 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature