MicroRNAs from edible plants reach the human gastrointestinal tract and may act as potential regulators of gene expression.

ABSTRACT: MicroRNAs (miRNAs) are small single-stranded non-coding RNA molecules that regulate gene expression at the post-transcriptional level. A cross-kingdom regulatory function has been unveiled for plant miRNAs (xenomiRs), which could shape inter-species interactions of plants with other organisms (bacteria and humans) and thus, be key functional molecules of plant-based food in mammals. However, discrepancies regarding the stability and bioavailability of dietary plant miRNAs on the host cast in doubt whether these molecules could have a significant impact on human physiology. The aim of the present study was to identify miRNAs in edible plants and determine their bioavailability on humans after an acute intake of plant-based products. It was found that plant food, including fruits, vegetables

SUBMITTER: Diez-Sainz E 

PROVIDER: S-EPMC11502557 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature