Human TRPV1 is an efficient thermogenetic actuator for chronic neuromodulation.

ABSTRACT: Thermogenetics is a promising neuromodulation technique based on the use of heat-sensitive ion channels. However, on the way to its clinical application, a number of questions have to be addressed. First, to avoid immune response in future human applications, human ion channels should be studied as thermogenetic actuators. Second, heating levels necessary to activate these channels in vivo in brain tissue should be studied and cytotoxicity of these temperatures addressed. Third, the possibility and safety of chronic neuromodulation has to be demonstrated. In this study, we present a comprehensive framework for thermogenetic neuromodulation in vivo using the thermosensitive human ion channel hTRPV1. By targeting hTRPV1 expression to excitatory neurons of the mouse brain and activating them

SUBMITTER: Maltsev DI 

PROVIDER: S-EPMC11502623 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature