Nucleoside and non-nucleoside reverse transcriptase inhibitor drugs (NRTIs and NNRTIs) are capable of binding Chandipura virus polymerase protein (L) and inhibit virus replication.

ABSTRACT: Chandipura virus (CHPV) is an emerging pathogen of Indian subcontinent. It is a vector borne virus and belongs to Rhabdovirus family. In recent past several outbreaks reported from the states of "Maharastha", "Gujrat", "Andra Pradesh" causing more than 300 deaths of children below 15 years and case-fatality rate was more than 50%. There is no targeted drug or vaccine available against CHPV and symptomatic treatment is the option. We hypothesized that nucleoside and non-nucleoside reverse transcriptase inhibitor drugs will be able to inhibit CHPV replication because of close structural similarity of the viral polymerases within the finger, palm and thumb domains. We examined the inhibitory effects of NRTI drugs AZT, tenofovir, abacavir and NNRTI drug nevirapine on CHPV replication in Vero c

SUBMITTER: Mandal D 

PROVIDER: S-EPMC11502645 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature