Interferon as an immunoadjuvant to enhance antibodies following influenza B infection and vaccination in ferrets.

ABSTRACT: Despite annual vaccination, influenza B viruses (IBV) continue to cause significant morbidity and mortality in humans. We have found that IBV infection resulted in a weaker innate and adaptive immune response than influenza A viruses (IAV) in ferrets. To understand and overcome the weak immune responses to IBV in ferrets, we administered type-I or type-III interferon (IFN) to ferrets following infection or vaccination and evaluated their effects on the immune response. IFN signaling following viral infection plays an important role in the initial innate immune response and affects subsequent adaptive immune responses. In the respiratory tract, IFN lambda (IFNL) has regulatory effects on adaptive immunity indirectly through thymic stromal lymphopoietin (TSLP), which then acts on immune cell

SUBMITTER: Rowe T 

PROVIDER: S-EPMC11502657 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature