Measuring the dynamic balance of integration and segregation underlying consciousness, anesthesia, and sleep in humans.

ABSTRACT: Consciousness requires a dynamic balance of integration and segregation in brain networks. We report an fMRI-based metric, the integration-segregation difference (ISD), which captures two key network properties: network efficiency (integration) and clustering (segregation). With this metric, we quantify brain state transitions from conscious wakefulness to unresponsiveness induced by the anesthetic propofol. The observed changes in ISD suggest a profound shift towards the segregation of brain networks during anesthesia. A common unimodal-transmodal sequence of disintegration and reintegration occurs in brain networks during, respectively, loss and return of responsiveness. Machine learning models using integration and segregation data accurately identify awake vs. unresponsive states and t

SUBMITTER: Jang H 

PROVIDER: S-EPMC11502666 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature