SNX5 promotes antigen presentation in B cells by dual regulation of actin and lysosomal dynamics.

ABSTRACT: B cells rapidly adapt their endocytic pathway to promote the uptake and processing of extracellular antigens recognized through the B-cell receptor (BCR). The mechanisms coupling changes in endomembrane trafficking to the capacity of B cells to screen for antigens within lymphoid tissues remain unaddressed. We investigated the role of SNX5, a member of the sorting nexin family, which interacts with endocytic membranes to regulate vesicular trafficking and macropinocytosis. Our results show that in steady state, B cells form SNX5-rich protrusions at the plasma membrane, which dissipate upon interaction with soluble antigens, whereas B cells activated with immobilized antigens accumulate SNX5 at the immune synapse where it regulates actin-dependent spreading responses. B cells silenced for S

SUBMITTER: Cabrera-Reyes F 

PROVIDER: S-EPMC11502673 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature