Beta vulgaris L. beetroot protects against iron-induced liver injury by restoring antioxidant pathways and regulating cellular functions.

ABSTRACT: Beta vulgaris L. is a root vegetable that is consumed mainly as a food additive. This study aimed to describe the protective effect of B. vulgaris on Fe²⁺-mediated oxidative liver damage through in vitro, ex vivo, and in silico studies to establish a strong rationale for its protective effect. To induce oxidative damage, we incubated the livers of healthy male rats with 0.1 mM FeSO₄ to induce oxidative injury and coincubated them with an aqueous extract of B. vulgaris root (BVFE) (15-240 µg/mL). Induction of liver damage significantly (p < .05) decreased the levels of GSH, SOD, CAT, and ENTPDase activities, with a corresponding increase in MDA and NO levels and Na⁺/K⁺ ATPase, G6 Pase, and F-1,6-BPase enzyme activities. BVFE treatment (p < .05) re

SUBMITTER: Ojo OA 

PROVIDER: S-EPMC11502780 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature