Early pregnancy hyperglycaemia among pregnant women with risk factors for gestational diabetes increases the risk of pregnancy complications.

ABSTRACT: The current diagnostic criteria for gestational diabetes (GDM) were based on data from women after 24 weeks of gestation, but this may not be equally applicable for earlier gestation. There is insufficient data regarding early pregnancy glycaemia and the associated complications. We retrospectively reviewed 39,483 deliveries and 12,918 with risk factors for GDM underwent oral glucose tolerance test (OGTT) before 24 weeks of gestation. A strong and progressively positive association was observed with any pregnancy complications in both fasting glucose (FG) and 2 h glucose (2hG). The increased risk of developing any pregnancy complications started from FG 4.5-4.7 mmol/L and 2hG of 6.2-6.9mmol/L. Every increase by 1 mmol/L in FG or 2 hG levels increased the risk of developing any complication

SUBMITTER: Cheung KW 

PROVIDER: S-EPMC11502845 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature