Association between change in serum uric acid and rapid decline in kidney function in China.

ABSTRACT: While the elevation of serum uric acid (SUA) is acknowledged as a risk factor for chronic kidney disease, the independent extent to which variations in SUA levels are correlated with temporal changes in estimated glomerular filtration rate (eGFR) remains uncertain. In light of this uncertainty, our research endeavored to elucidate the temporal associations between change in SUA and rapid eGFR decline in China. In this longitudinal study of China's middle-aged and elderly between 2011 and 2015, we analyzed 5421 individuals with complete SUA and eGFR data. Logistic regression was applied to evaluate the risk factors associated with a rapid eGFR decline (defined by a 5 mL/min/1.73 m² decrease or falling to less than 15 mL/min/1.73 m² by 2015), adjusted for age, gender, m

SUBMITTER: Li Y 

PROVIDER: S-EPMC11502876 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature