Effects of separate and combined estradiol and progesterone administration on fear extinction in healthy pre-menopausal women.

ABSTRACT: Altered fear conditioning and extinction learning are discussed as key etiological features in anxiety disorders. Women have an increased risk for anxiety disorders and fear conditioning has been shown to be influenced by the menstrual cycle phase and circulating gonadal hormones. The objective of our study was to investigate the effects of separate and combined estradiol and progesterone administration on fear extinction in healthy women. We conducted a placebo-controlled, randomized study in healthy women, who completed a fear conditioning paradigm on three consecutive days: fear acquisition training on day 1, fear extinction training on day 2, and return of fear test on day 3. Skin conductance responses (SCRs) served as main outcome variable. Two hours before testing on day 2, participa

SUBMITTER: Kaczmarczyk M 

PROVIDER: S-EPMC11502897 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature