Sleep deprivation and aging are metabolically linked across tissues.

ABSTRACT:

Study objectives

Insufficient sleep is a concerning hallmark of modern society because sleep deprivation (SD) is a risk factor for neurodegenerative and cardiometabolic disorders. SD imparts an aging-like effect on learning and memory, although little is known about possible common molecular underpinnings of SD and aging. Here, we examine this question by profiling metabolic features across different tissues after acute SD in young adult and aged mice.

Methods

Young adult and aged mice were subjected to acute SD for 5 hours. Blood plasma, hippocampus, and liver samples were subjected to UPLC-MS/MS-based metabolic profiling.

Results

SD preferentially impacts peripheral plasma and liver profiles (e.g. ketone body metabolism) whereas the hippocampus is more impacted by a

SUBMITTER: Sengupta A 

PROVIDER: S-EPMC11502955 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature