Association between premature vascular smooth muscle cells senescence and vascular inflammation in Takayasu's arteritis.

ABSTRACT:

Objectives

Arterial wall inflammation and remodelling are the characteristic features of Takayasu's arteritis (TAK). It has been proposed that vascular smooth muscle cells (VSMCs) are the main targeted cells of inflammatory damage and participate in arterial remodelling in TAK. Whether VSMCs are actively involved in arterial wall inflammation has not been elucidated. Studies have shown that cellular senescence in tissue is closely related to local inflammation persistence. We aimed to investigate whether VSMCs senescence contributes to vascular inflammation and the prosenescent factors in TAK.

Methods

VSMCs senescence and senescence-associated secretory phenotype were detected by histological examination, bulk RNA-Seq and single-cell RNA-seq conducted on vascular surgery sam

SUBMITTER: Fang C 

PROVIDER: S-EPMC11503059 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature