Trajectories of self-reported fatigue following initiation of multiple sclerosis disease-modifying therapy.

ABSTRACT:

Background

We analysed the COMparison Between All immunoTherapies for Multiple Sclerosis (NCT03193866), a Swedish nationwide observational study in relapsing-remitting multiple sclerosis (RRMS), to identify trajectories of fatigue and their association with physical disability following start of disease-modifying therapy (DMT).

Methods

Using a group-modelling approach, we assessed trajectories of fatigue with the Fatigue Scale for Motor and Cognitive Functions and physical disability with Expanded Disability Status Scale among 1587 and 1818 individuals who initiated a first DMT and had a first DMT switch, respectively, followed during 2011-2022. We investigated predictors of fatigue trajectories using group membership as a multinomial outcome and calculated conditional proba

SUBMITTER: Englund S 

PROVIDER: S-EPMC11503085 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature