Pathogenesis of multiple sclerosis: genetic, environmental and random mechanisms.

ABSTRACT:

Background

The pathogenesis of multiple sclerosis (MS) requires both genetic factors and environmental events. The question remains, however, whether these factors and events completely describe the MS disease process. This question was addressed using the Canadian MS data, which includes 29 478 individuals, estimated to represent 65-83% of all Canadian patients with MS.

Method

The 'genetically-susceptible' subset of the population, (G), includes everyone who has any non-zero life-time chance of developing MS, under some environmental conditions. A 'sufficient' environmental exposure, for any genetically-susceptible individual, includes every set of environmental conditions, each of which is 'sufficient', by itself, to cause MS in that person. This analysis incorporat

SUBMITTER: Goodin DS 

PROVIDER: S-EPMC11503101 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature