Gut microbiota signatures of vulnerability to food addiction in mice and humans.

ABSTRACT:

Objective

Food addiction is a multifactorial disorder characterised by a loss of control over food intake that may promote obesity and alter gut microbiota composition. We have investigated the potential involvement of the gut microbiota in the mechanisms underlying food addiction.

Design

We used the Yale Food Addiction Scale (YFAS) 2.0 criteria to classify extreme food addiction in mouse and human subpopulations to identify gut microbiota signatures associated with vulnerability to this disorder.

Results

Both animal and human cohorts showed important similarities in the gut microbiota signatures linked to food addiction. The signatures suggested possible non-beneficial effects of bacteria belonging to the Proteobacteria phylum and potential protective effects of Acti

SUBMITTER: Samulenaite S 

PROVIDER: S-EPMC11503113 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature