Management of low-level HIV viremia during antiretroviral therapy: Delphi consensus statement and appraisal of the evidence.

ABSTRACT:

Objective

While antiretroviral therapy (ART) is highly effective, detection of low levels of HIV-1 RNA in plasma is common in treated individuals. Given the uncertainties on the topic, we convened a panel of experts to consider different clinical scenarios, producing a Delphi consensus to help guide clinical practice.

Methods

A panel of 17 experts in infectious diseases, virology and immunology rated 32 statements related to four distinct scenarios: (1) low-level viremia during stable (≥6 months) first-line ART (≥2 consecutive HIV-1 RNA measurements 50-500 copies/mL); (2) a viral blip during otherwise suppressive ART (a HIV-1 RNA measurement 50-1000 copies/mL with adjacent measurements <50 copies/mL); (3) low-level viral rebound during previously suppressive ART (≥2 consecut

SUBMITTER: Rindi LV 

PROVIDER: S-EPMC11503133 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature