Lifetime effects and cost-effectiveness of statin therapy for older people in the United Kingdom: a modelling study.

ABSTRACT:

Background

Cardiovascular disease (CVD) risk increases with age. Statins reduce cardiovascular risk but their effects are less certain at older ages. We assessed the long-term effects and cost-effectiveness of statin therapy for older people in the contemporary UK population using a recent meta-analysis of randomised evidence of statin effects in older people and a new validated CVD model.

Methods

The performance of the CVD microsimulation model, developed using the Cholesterol Treatment Trialists' Collaboration (CTTC) and UK Biobank cohort, was assessed among participants ≥70 years old at (re)surveys in UK Biobank and the Whitehall II studies. The model projected participants' cardiovascular risks, survival, quality-adjusted life years (QALYs) and healthcare costs (2021 UK£

SUBMITTER: Mihaylova B 

PROVIDER: S-EPMC11503164 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature