Implications of the 2022 lung function update and GLI global reference equations among patients with interstitial lung disease.

ABSTRACT:

Background

Lung function testing remains a cornerstone in the assessment and management of interstitial lung disease (ILD) patients. The clinical implications of the Global Lung function Initiative (GLI) reference equations and the updated interpretation strategies remain uncertain.

Methods

Adult patients with ILD with baseline forced vital capacity (FVC) were included from the Australasian ILD registry and the National Healthcare Group ILD registry, Singapore.The European Coal and Steel Community and Miller reference equations were compared with the GLI reference equations to assess (a) differences in lung function percent predicted values; (b) ILD risk prediction models and (c) eligibility for ILD clinical trial enrolment.

Results

Among 2219 patients with ILD, 1712

SUBMITTER: Li A 

PROVIDER: S-EPMC11503192 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature