Diagnostic accuracy of alternative biomarkers for acute aortic syndrome: a systematic review.

ABSTRACT:

Background

D-dimer is the only biomarker currently recommended in guidelines for the diagnosis of acute aortic syndrome (AAS). We undertook a systematic review to determine whether any alternative biomarkers could be useful in AAS diagnosis.

Methods

We searched electronic databases (including MEDLINE, EMBASE and the Cochrane Library) from inception to February 2024. Diagnostic studies were eligible if they examined biomarkers other than D-dimer for diagnosing AAS compared with a reference standard test in people presenting to the ED with symptoms of AAS. Case-control studies were identified but excluded due to high risk of bias. Selection of studies, data extraction and risk of bias assessments using the Quality Assessment of Diagnostic Accuracy Studies 2 (QUADAS-2) tool wer

SUBMITTER: Wren J 

PROVIDER: S-EPMC11503200 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature