Clinical significance of ribosomal protein S15 expression in patients with colorectal cancer liver metastases.

ABSTRACT:

Background

Liver metastasis is the most frequently observed distant metastasis of colorectal cancer, and the residual liver recurrence rate after hepatic resection is still high. To explore the mechanism of liver metastasis to discover potential new treatments, we assessed the relationship between the expression of differentially expressed genes (DEGs) and prognosis in patients with colorectal cancer liver metastasis (CRLM).

Methods

The gene expression dataset was extracted from The Cancer Genome Atlas and the Gene Expression Omnibus. Significance analysis of DEGs between tumor and normal samples of colorectum, liver, and lung was conducted. A total of 80 CRLM patients were studied to assess the expression of RPS15, characteristics, and outcomes. We examined the relationship

SUBMITTER: Sakano Y 

PROVIDER: S-EPMC11503462 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature