Copper-61 is an advantageous alternative to gallium-68 for PET imaging of somatostatin receptor-expressing tumors: a head-to-head comparative preclinical study.

ABSTRACT:

Background

Gallium-68 positron emission tomography (⁶⁸Ga-PET) with the two registered somatostatin analogs, [⁶⁸Ga]Ga-DOTA-Tyr³-octreotide ([⁶⁸Ga]Ga-DOTA-TOC) and [⁶⁸Ga]Ga-DOTA-Tyr³-octreotate ([⁶⁸Ga]Ga-DOTA-TATE), where DOTA = 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid, is routinely used for imaging of somatostatin receptor (SST)-expressing tumors. We investigated copper-61 (⁶¹Cu) as an alternative radiometal for PET imaging of SST-expressing tumors. Compared to gallium-68, copper-61 (t_1/2 = 3.33 h, E _β ⁺ _max = 1.22 MeV) can be produced on a large scale, enables late time point imaging, and has the therapeutic twin copper-67. Herei

SUBMITTER: Basaco Bernabeu T 

PROVIDER: S-EPMC11503464 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature