Inserting Three-Coordinate Nickel into [4Fe-4S] Clusters.

ABSTRACT: Metalloenzymes can efficiently achieve the multielectron interconversion of carbon dioxide and carbon monoxide under mild conditions. Anaerobic carbon monoxide dehydrogenase (CODH) performs these reactions at the C cluster, a unique nickel-iron-sulfide cluster that features an apparent three-coordinate nickel site. How nature assembles the [NiFe₃S₄]-Fe_u cluster is not well understood. We use synthetic clusters to demonstrate that electron transfer can drive insertion of a Ni⁰ precursor into an [Fe₄S₄]³⁺ cluster to assemble higher nuclearity nickel-iron-sulfide clusters with the same complement of metal ions as the C cluster. Initial electron transfer results in a [1Ni-4Fe-4S] cluster in which a Ni

SUBMITTER: Fataftah MS 

PROVIDER: S-EPMC11503493 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature