Potential mechanisms of metabolic reprogramming induced by ischemia-reperfusion injury in diabetic myocardium.

ABSTRACT:

Objective

This study aimed to explore metabolic reprogramming in diabetic myocardium subjected to ischemia-reperfusion injury (I/RI) and potential mechanisms.

Background

Increased vulnerability after I/RI in diabetic myocardium is a major cause of the high prevalence of perioperative adverse cardiac events, and the specific alterations in energy metabolism after I/RI in diabetic myocardium and the impact on increased vulnerability are not fully understood.

Methods

Metabolomic methods were used to explore the differences and characteristics of metabolites in the heart tissues of four groups, and then, single-cell RNA sequencing (ScRNA-seq) was used to explore the potential mechanism of metabolic reprogramming.

Results

It was found that the fatty acid metabolism

SUBMITTER: Ma H 

PROVIDER: S-EPMC11503499 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature