Integrated microfluidic multiple electrode aggregometry for point-of-care platelet function analysis.

ABSTRACT: Point-of-care (POC) platelet function analysis can enable timely and precise management of bleeding and clotting in emergency rooms, operation rooms and intensive care units. However, POC platelet testing is currently not commonly performed, due to the complexity of sample preparation and limitations of existing technologies. Here, we report the development of an integrated microfluidic multiple electrode aggregometry (μMEA) sensor which uses multi-frequency impedance measurement of an embedded microelectrode array to perform platelet aggregometry directly from whole blood, sensing and measuring platelet activation in a label-free manner and without requiring any additional sample preparation. Additionally, the sensor incorporates blood flow during the assay to account for physiological fl

SUBMITTER: Zhao X 

PROVIDER: S-EPMC11503524 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature