Development of a pharmacological evidence-based anticholinergic burden scale for medications commonly used in older adults.

ABSTRACT:

Aim

The present study aimed to develop a pharmacological evidence-based anticholinergic burden scale (ABS) through a direct assessment of muscarinic receptor-binding activities of 260 medications commonly used in older adults.

Methods

The muscarinic receptor-binding activities of 260 drugs were assessed by the displacement of specific [N-methyl-³ H]scopolamine methyl chloride binding in the rat brain. The maximum blood concentrations (C_max ) of drugs after their administration to subjects were cited from their interview forms.

Results

In total, 96 of 260 drugs displayed concentration-dependent muscarinic receptor binding in rat brain. Based on muscarinic receptor-binding activity (IC₅₀ ) and C_max after the administration at

SUBMITTER: Yamada S 

PROVIDER: S-EPMC11503540 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature