Accumulation of polyunsaturated fatty acid-derived metabolites in the sarcopenic muscle of aging mice.

ABSTRACT:

Aim

Although it is known that advanced age alters skeletal muscle lipid metabolism, the role(s) of polyunsaturated fatty acid-derived metabolites (mostly eicosanoids and docosanoids) in sarcopenia are not clear. We therefore examined the changes in the metabolites of arachidonic acid, eicosapentaenoic acid and docosahexaenoic acid in the sarcopenic muscle of aged mice.

Methods

We used 6- and 24-month-old male C57BL/6J mice as healthy and sarcopenic muscle models, respectively. Skeletal muscles were removed from the lower limb and subjected to a liquid chromatography-tandem mass spectrometry analysis.

Results

The liquid chromatography-tandem mass spectrometry analysis detected distinct changes of metabolites in the muscles of the aged mice. Of the 63 metabolites identi

SUBMITTER: Kadoguchi T 

PROVIDER: S-EPMC11503557 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature