Constructing the dynamic transcriptional regulatory networks to identify phenotype-specific transcription regulators.

ABSTRACT: The transcriptional regulatory network (TRN) is a graph framework that helps understand the complex transcriptional regulation mechanisms in the transcription process. Identifying the phenotype-specific transcription regulators is vital to reveal the functional roles of transcription elements in associating the specific phenotypes. Although many methods have been developed towards detecting the phenotype-specific transcription elements based on the static TRN in the past decade, most of them are not satisfactory for elucidating the phenotype-related functional roles of transcription regulators in multiple levels, as the dynamic characteristics of transcription regulators are usually ignored in static models. In this study, we introduce a novel framework called DTGN to identify the phenotyp

SUBMITTER: Guo Y 

PROVIDER: S-EPMC11503644 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature