Prognostic nomograms for young breast cancer: A retrospective study based on the SEER and METABRIC databases.

ABSTRACT:

Background

Young breast cancer (YBC) is a subset of breast cancer that is often more aggressive, but less is known about its prognosis. In this study, we aimed to generate nomograms to predict the overall survival (OS) and breast cancer-specific survival (BCSS) of YBC patients.

Methods

Data of women diagnosed with YBC between 2010 and 2020 were obtained from the Surveillance, Epidemiology, and End Results (SEER) database. The patients were randomly allocated into a training cohort (n = 15,227) and internal validation cohort (n = 6,526) at a 7:3 ratio. With the Cox regression models, significant prognostic factors were identified and used to construct 3-, 5-, and 10-year nomograms of OS and BCSS. Data from the Molecular Taxonomy of Breast Cancer International Co

SUBMITTER: Li Y 

PROVIDER: S-EPMC11503687 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature