Regiodivergent Radical-Relay Alkene Dicarbofunctionalization.

ABSTRACT: Herein, we report a regiodivergent 1,n-dicarbofunctionalization of unactivated olefins enabled by a Ni-catalyzed radical relay that forges both C(sp³)-C(sp³) and C(sp²)-C(sp³) linkages, even at long-range. Initial studies support an intertwined scenario resulting from the merger of an atom-transfer radical addition (ATRA) and a chain-walking event, with site-selectivity being dictated by a judicious choice of the ligand backbone.

SUBMITTER: Liu Z 

PROVIDER: S-EPMC11503781 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature