Stick, Slide, or Bounce: Charge Density Controls Nanoparticle Diffusion.

ABSTRACT: The diffusion and interaction dynamics of charged nanoparticles (NPs) within charged polymer networks are crucial for understanding various biological and biomedical applications. Using a combination of coarse-grained molecular dynamics simulations and experimental diffusion studies, we investigate the effects of the NP size, relative surface charge density (ζ), and concentration on the NP permeation length and time. We propose a scaling law for the relative diffusion of NPs with respect to concentration and ζ, highlighting how these factors influence the NP movement within the network. The analyses reveal that concentration and ζ significantly affect NP permeation length and time, with ζ being critical, as critical as concentration. This finding is corroborated by controlled release exper

SUBMITTER: Motezakker AR 

PROVIDER: S-EPMC11503907 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature