Exercise-Induced Proteomic Profile Changes in Patients with Advanced Heart Failure.

ABSTRACT:

Background/objectives

The pathophysiological background of the processes activated by physical activity in patients with heart failure (HF) is not fully understood. Proteomic studies can help to preliminarily identify new protein markers for unknown or poorly defined physiological processes. We aimed to analyse the changes in the plasma proteomic profile of HF patients after a cardiopulmonary exercise test (CPET) to define pathways involved in the response to exercise.

Methods

The study prospectively enrolled 20 male patients with advanced HF (aged 53.3 ± 8.3 years). Blood samples were taken from the patients before and immediately after the CPET to obtain plasma proteomic profiles. Two-sample t-tests (paired or non-paired) were performed with and without false discov

SUBMITTER: Drohomirecka A 

PROVIDER: S-EPMC11503997 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature